A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

Guste Urbonaite and Jimmy Tsz Hang Lee et al. present a droplet-based single-cell sequencing method optimized for use in yeast. They use their method—yeastDropSeq—to investigate the changes in gene expression profiles following treatment with the lifespan-extending compound mycophenolic acid and/or...

Full description

Bibliographic Details
Main Authors:	Guste Urbonaite, Jimmy Tsz Hang Lee, Ping Liu, Guillermo E. Parada, Martin Hemberg, Murat Acar
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02320-w

Similar Items

Author Correction: A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels
by: Guste Urbonaite, et al.
Published: (2021-07-01)

Quantitative Insights into Age-Associated DNA-Repair Inefficiency in Single Cells
by: Thomas Z. Young, et al.
Published: (2019-08-01)

Expression of IMPDH mRNA after Mycophenolate Administration in Male Volunteers
by: Sollip Kim, et al.
Published: (2014-01-01)

High guanine and cytosine content increases mRNA levels in mammalian cells.
by: Grzegorz Kudla, et al.
Published: (2006-06-01)

Diversity of Parallel Guanine Quadruplexes Induced by Guanine Substitutions
by: Klára Bednářová, et al.
Published: (2020-08-01)

Determination of the Global Pattern of Gene Expression in Yeast Cells by Intracellular Levels of Guanine Nucleotides
by: Andy Hesketh, et al.
Published: (2019-01-01)

Products of Oxidative Guanine Damage Form Base Pairs with Guanine
by: Katsuhito Kino, et al.
Published: (2020-10-01)

Mycophenolate mofetil alters the antioxidant status in duodenum of rats: Implication for silymarin usage in mycophenolate mofetil induced gastrointestinal disorders
by: Sanaz Sheikhzadeh, et al.
Published: (2013-06-01)

Mycophenolate mofetil and atherosclerosis
by: Z S Alekberova, et al.
Published: (2009-10-01)

Multisite phosphorylation of the guanine nucleotide exchange factor Cdc24 during yeast cell polarization.
by: Stephanie C Wai, et al.
Published: (2009-08-01)

Calculation of the Stabilization Energies of Oxidatively Damaged Guanine Base Pairs with Guanine
by: Hiroshi Miyazawa, et al.
Published: (2012-06-01)

Evaluation of genome designs for oxidation resistance: guanine minimization and scavenger guanine
by: Friedman, Keith Albert
Published: (2008)

Yeast Replicator: A High-Throughput Multiplexed Microfluidics Platform for Automated Measurements of Single-Cell Aging
by: Ping Liu, et al.
Published: (2015-10-01)

Tautomerism of Guanine Analogues
by: Jakub Radek Štoček, et al.
Published: (2020-01-01)

Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast.
by: Alan M Eckler, et al.
Published: (2013-01-01)

Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6.
by: Alison K Gillingham, et al.
Published: (2007-09-01)

Immunogenicity of repeat COVID-19 mRNA vaccinations in a patient with myasthenia gravis receiving mycophenolate, prednisone, and eculizumab
by: Lisa C. Plymate, MD, et al.
Published: (2021-01-01)

Is Conversion from Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium Justifiable for Gastrointestinal Quality of Life?
by: Kyle M. Gardiner, et al.
Published: (2018-11-01)

Elucidating the mechanism of mRNA translation during Drosophila oogenesis
by: Davidson, Alexander
Published: (2015)

ELUCIDATION OF REGULATORY MECHANISMS OF TRANSCRIPTION AND COUPLED mRNA EXPORT
by: Durairaj, Geetha
Published: (2013)

Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast
by: Ulschan Scheler, et al.
Published: (2016-10-01)

Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing
by: Kewu Pan, et al.
Published: (2015-03-01)

Purification, characterization and substrate specificity of a nuclear mRNA (Guanine-7)-Methyltransferase from Ehrlich ascites cells
by: Bu, Guojun
Published: (2014)

Sites of gastrointestinal lesion induced by mycophenolate mofetil: a comparison with enteric-coated mycophenolate sodium in rats
by: Yichen Jia, et al.
Published: (2018-07-01)

The Effect of Cyclosporine、Tacrolimus and Sirolimus on the Concentration of Mycophenolic Acid in Renal Transplant Recipients Taking Mycophenolate Mofetil
by: Chih-Yuan Lee, et al.
Published: (2007)

Utilisation de gabarits peptidiques pour le contrôle de l'auto-assemblage de dérivés de la Guanine : Des tétrades de guanines aux quadruplexes d'acides nucléiques.
by: Murat, Pierre
Published: (2010)

Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites
by: Kyung Ah Cheong, et al.
Published: (2020-04-01)

Mycophenolate versus cyclophosphamide for lupus nephritis
by: M Sahay, et al.
Published: (2018-01-01)

Modifications of total synthesis of mycophenolic acid
by: Grzegorz Cholewinski, et al.
Published: (2018-02-01)

Mycophenolate mofetil in the treatment of lupus nephritis
by: Patrick FK Yong, et al.
Published: (2008-06-01)

Studies on mycophenolic acid and lignan chemistry
by: Knittel, Peter
Published: (2011)

Anti-Vasculogenic Effect of Mycophenolic Acid
by: Go, Ellen Lao
Published: (2019)

Elucidating the Mechanism of mRNA Export Regulation by the Nuclear Pore Complex
by: Cai, Sarah Wang
Published: (2018)

Elucidating the biological functions of the appended domain of yeast ValRS
by: Chia-Jung Hsieh, et al.
Published: (2002)

Elucidation of the Mechanisms of Glucose Starvation on Mitochondria Dynamics in Yeast Cells
by: Huang, Hsin Wei, et al.
Published: (2015)

Calculating Distortions of Short DNA Duplexes with Base Pairing Between an Oxidatively Damaged Guanine and a Guanine
by: Masayo Suzuki, et al.
Published: (2014-07-01)

An integrated transcriptomics and metabolomics study of the immune response of newly hatched chicks to the cytosine-phosphate-guanine oligonucleotide stimulation
by: Djomangan Adama Ouattara, et al.
Published: (2020-09-01)

MRNA degradation in the control of gene expression in yeast
by: Brown, Justin Travis
Published: (2011)

Regulation of yeast development by mRNA methylation
by: Agarwala, Sudeep D
Published: (2012)

Selectivity of mRNA degradation by autophagy in yeast
by: Shiho Makino, et al.
Published: (2021-04-01)