A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

Guste Urbonaite and Jimmy Tsz Hang Lee et al. present a droplet-based single-cell sequencing method optimized for use in yeast. They use their method—yeastDropSeq—to investigate the changes in gene expression profiles following treatment with the lifespan-extending compound mycophenolic acid and/or...

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Main Authors: Guste Urbonaite, Jimmy Tsz Hang Lee, Ping Liu, Guillermo E. Parada, Martin Hemberg, Murat Acar
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02320-w
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spelling doaj-2ae30661d9c24c4f974d766b45d014252021-07-04T11:13:54ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111010.1038/s42003-021-02320-wA yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levelsGuste Urbonaite0Jimmy Tsz Hang Lee1Ping Liu2Guillermo E. Parada3Martin Hemberg4Murat Acar5Systems Biology Institute, Yale UniversityWellcome Sanger Institute, Wellcome Genome CampusSystems Biology Institute, Yale UniversityWellcome Sanger Institute, Wellcome Genome CampusWellcome Sanger Institute, Wellcome Genome CampusSystems Biology Institute, Yale UniversityGuste Urbonaite and Jimmy Tsz Hang Lee et al. present a droplet-based single-cell sequencing method optimized for use in yeast. They use their method—yeastDropSeq—to investigate the changes in gene expression profiles following treatment with the lifespan-extending compound mycophenolic acid and/or its epistatic agent, guanine.https://doi.org/10.1038/s42003-021-02320-w
collection DOAJ
language English
format Article
sources DOAJ
author Guste Urbonaite
Jimmy Tsz Hang Lee
Ping Liu
Guillermo E. Parada
Martin Hemberg
Murat Acar
spellingShingle Guste Urbonaite
Jimmy Tsz Hang Lee
Ping Liu
Guillermo E. Parada
Martin Hemberg
Murat Acar
A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels
Communications Biology
author_facet Guste Urbonaite
Jimmy Tsz Hang Lee
Ping Liu
Guillermo E. Parada
Martin Hemberg
Murat Acar
author_sort Guste Urbonaite
title A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels
title_short A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels
title_full A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels
title_fullStr A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels
title_full_unstemmed A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels
title_sort yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mrna levels
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-06-01
description Guste Urbonaite and Jimmy Tsz Hang Lee et al. present a droplet-based single-cell sequencing method optimized for use in yeast. They use their method—yeastDropSeq—to investigate the changes in gene expression profiles following treatment with the lifespan-extending compound mycophenolic acid and/or its epistatic agent, guanine.
url https://doi.org/10.1038/s42003-021-02320-w
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