Role of Hypoxia in the Control of the Cell Cycle

Role of Hypoxia in the Control of the Cell Cycle

The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role...

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Bibliographic Details
Main Authors: Jimena Druker, James W. Wilson, Fraser Child, Dilem Shakir, Temitope Fasanya, Sonia Rocha
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
cell cycle
HIF
PHDs
2-OGDs
mitosis
Online Access:https://www.mdpi.com/1422-0067/22/9/4874
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spelling doaj-2adf038e102c44f984b5c25f94c044b42021-05-31T23:13:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01224874487410.3390/ijms22094874Role of Hypoxia in the Control of the Cell CycleJimena Druker0James W. Wilson1Fraser Child2Dilem Shakir3Temitope Fasanya4Sonia Rocha5Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UKDepartment of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UKDepartment of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UKDepartment of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UKDepartment of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UKDepartment of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UKThe cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.https://www.mdpi.com/1422-0067/22/9/4874hypoxiacell cycleHIFPHDs2-OGDsmitosis
collection DOAJ
language English
format Article
sources DOAJ
author Jimena Druker
James W. Wilson
Fraser Child
Dilem Shakir
Temitope Fasanya
Sonia Rocha
spellingShingle Jimena Druker
James W. Wilson
Fraser Child
Dilem Shakir
Temitope Fasanya
Sonia Rocha
Role of Hypoxia in the Control of the Cell Cycle
International Journal of Molecular Sciences
hypoxia
cell cycle
HIF
PHDs
2-OGDs
mitosis
author_facet Jimena Druker
James W. Wilson
Fraser Child
Dilem Shakir
Temitope Fasanya
Sonia Rocha
author_sort Jimena Druker
title Role of Hypoxia in the Control of the Cell Cycle
title_short Role of Hypoxia in the Control of the Cell Cycle
title_full Role of Hypoxia in the Control of the Cell Cycle
title_fullStr Role of Hypoxia in the Control of the Cell Cycle
title_full_unstemmed Role of Hypoxia in the Control of the Cell Cycle
title_sort role of hypoxia in the control of the cell cycle
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-05-01
description The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.
topic hypoxia
cell cycle
HIF
PHDs
2-OGDs
mitosis
url https://www.mdpi.com/1422-0067/22/9/4874
work_keys_str_mv AT jimenadruker roleofhypoxiainthecontrolofthecellcycle
AT jameswwilson roleofhypoxiainthecontrolofthecellcycle
AT fraserchild roleofhypoxiainthecontrolofthecellcycle
AT dilemshakir roleofhypoxiainthecontrolofthecellcycle
AT temitopefasanya roleofhypoxiainthecontrolofthecellcycle
AT soniarocha roleofhypoxiainthecontrolofthecellcycle
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