Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway

Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway

Shouhai Wu,1,2 Tianpeng Zhang,1 Jingsheng Du3 1School of Life Sciences, Sun Yat-sen University, 2Center for Regenerative and Translational Medicine, 3Department of Pharmacy, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic o...

Full description

Bibliographic Details
Main Authors:	Wu S, Zhang T, Du J
Format:	Article
Language:	English
Published:	Dove Medical Press 2016-10-01
Series:	Drug Design, Development and Therapy
Subjects:	ursolic acid chemoresistance cisplatin liver cancer Nrf2/ARE
Online Access:	https://www.dovepress.com/ursolic-acid-sensitizes-cisplatin-resistant-hepg2ddp-cells-to-cisplati-peer-reviewed-article-DDDT

Similar Items

Cryptotanshinone Reverses Cisplatin Resistance of Human Lung Carcinoma A549 Cells through Down-Regulating Nrf2 Pathway
by: Chen Xia, et al.
Published: (2015-09-01)

Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment
by: Lena Berning, et al.
Published: (2021-02-01)

Daphnetin Attenuated Cisplatin-Induced Acute Nephrotoxicity With Enhancing Antitumor Activity of Cisplatin by Upregulating SIRT1/SIRT6-Nrf2 Pathway
by: Xiaoye Fan, et al.
Published: (2020-12-01)

Evaluation of Cytotoxic Effects of Carnosic Acid Alone and Combination with Cisplatin in HepG2 Cells
by: Uğur Nuri Akın, et al.
Published: (2019-12-01)

ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer
by: Wenyu Wang, et al.
Published: (2020-11-01)

Emerging role of long non-coding RNAs in cisplatin resistance
by: Hu Y, et al.
Published: (2018-05-01)

Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells
by: Miguel Angel Merlos Rodrigo, et al.
Published: (2019-03-01)

The Role of Hexokinase II in the Regulation of Glycolysis and Cisplatin Sensitivity in Ovarian Cancer
by: Han, Chae Young
Published: (2018)

Pentoxifylline Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment: Involvement of Mitochondrial and NF-Kappa B Pathways
by: Alejandro Bravo-Cuellar, et al.
Published: (2020-12-01)

Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
by: Xiaoye Fan, et al.
Published: (2020-03-01)

Cisplatin-Induced Giant Cells Formation Is Involved in Chemoresistance of Melanoma Cells
by: Chien-Hui Weng, et al.
Published: (2020-10-01)

Identification of BXDC2 as a Key Downstream Effector of the Androgen Receptor in Modulating Cisplatin Sensitivity in Bladder Cancer
by: Guiyang Jiang, et al.
Published: (2021-02-01)

Matrix metalloproteinase 2 knockdown suppresses the proliferation of HepG2 and Huh7 cells and enhances the cisplatin effect
by: Liu Jiangwei, et al.
Published: (2019-05-01)

Extraction of ursolic acid from Ocimum sanctum and synthesis of its novel derivatives: effects on extracellular homocysteine, dihydrofolate reductase activity and proliferation of HepG2 human hepatoma cells
by: Batra Apsara, et al.
Published: (2013-12-01)

Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway
by: Hong Liao, et al.
Published: (2020-10-01)

Antioxidant Effects of Pinus eldarica Extracts Against Cisplatin-induced Cytotoxicity in Human Hepatoma (HepG2) Cell Line
by: Amin Sharifan, et al.
Published: (2021-05-01)

Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer
by: Masayuki Hagiwara, et al.
Published: (2018-01-01)

Cisplatin-resistant HepG2 cell-derived exosomes transfer cisplatin resistance to cisplatin-sensitive cells in HCC
by: Zuxiong Tang, et al.
Published: (2021-04-01)

Metabolomics Study on the Differences of Endogenous Small Molecule  between A549/DDP and A549 Cells Based on High Solution UPLC-TOF-MS
by: Weipeng HONG, et al.
Published: (2018-08-01)

Emerging role of NRF2 in ROS-mediated tumor chemoresistance
by: Danfeng Xue, et al.
Published: (2020-11-01)

CSNK2A1‐mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer
by: Zhan Shi, et al.
Published: (2021-08-01)

Forkhead Box Protein C2 (FOXC2) Promotes the Resistance of Human Ovarian Cancer Cells to Cisplatin In Vitro and In Vivo
by: Chanjuan Li, et al.
Published: (2016-06-01)

Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance
by: Milad Ashrafizadeh, et al.
Published: (2020-06-01)

Nrf2 in cancers: A double‐edged sword
by: Shijia Wu, et al.
Published: (2019-05-01)

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling
by: Dazhi Fu, et al.
Published: (2021-06-01)

Androgen Receptor Signaling Induces Cisplatin Resistance via Down-Regulating GULP1 Expression in Bladder Cancer
by: Yuki Teramoto, et al.
Published: (2021-09-01)

Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence
by: Luciana O. Almeida, et al.
Published: (2017-05-01)

Integrin Activation Contributes to Lower Cisplatin Sensitivity in MV3 Melanoma Cells by Inducing the Wnt Signalling Pathway
by: Maria B. R. Piva, et al.
Published: (2017-09-01)

LncRNA BANCR Attenuates the Killing Capacity of Cisplatin on Gastric Cancer Cell Through the ERK1/2 Pathway
by: Miao X, et al.
Published: (2021-01-01)

Prodigiosin Promotes Nrf2 Activation to Inhibit Oxidative Stress Induced by Microcystin-LR in HepG2 Cells
by: Jihua Chen, et al.
Published: (2019-07-01)

Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects
by: Cinzia Calcabrini, et al.
Published: (2020-05-01)

Ursolic Acid Inhibits Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury and Prevents Development of Lung Cancer
by: Siming Yu, et al.
Published: (2012-08-01)

circRNA circARNT2 Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting the miR-155-5p/PDK1 Axis
by: Yueyong Li, et al.
Published: (2021-03-01)

Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies
by: Kathleen Wantoch von Rekowski, et al.
Published: (2020-12-01)

The Effect and Mechanism of Vinorelbine on Cisplatin Resistance  of Human Lung Cancer Cell Line A549/DDP
by: Chunsheng QI, et al.
Published: (2014-02-01)

Arsenic sulfide reverses cisplatin resistance in non‐small cell lung cancer in vitro and in vivo through targeting PD‐L1
by: Wei Tian, et al.
Published: (2021-10-01)

Modulation of RAB7A Protein Expression Determines Resistance to Cisplatin through Late Endocytic Pathway Impairment and Extracellular Vesicular Secretion
by: Flora Guerra, et al.
Published: (2019-01-01)

Ursolic acid improves the bacterial community mapping of the intestinal tract in liver fibrosis mice
by: Sizhe Wan, et al.
Published: (2020-04-01)

Eckol Enhances Heme Oxygenase-1 Expression through Activation of Nrf2/JNK Pathway in HepG2 Cells
by: Young-Jin Jun, et al.
Published: (2014-09-01)

Effects of Phthalate Esters (PAEs) on Cell Viability and Nrf2 of HepG2 and 3D-QSAR Studies
by: Huan Liu, et al.
Published: (2021-06-01)