A 58-Year-Old Woman with Left-Sided Weakness and a History of a Pediatric Brain Tumor: A Case Report

• Main Authors: Shaakir Hasan, Michael J. Gigliotti, Melvin Deutsch, Stacey L. Reed, Rodney E. Wegner
• Format: Article
• Language: English
• Published: Karger Publishers 2018-03-01
• Series: Case Reports in Oncology
• Subjects: Meningioma; Radiation-induced glioma; Radiation therapy; Cerebral sarcoma; Glioblastoma multiforme
• Online Access: https://www.karger.com/Article/FullText/487430

Background: An uncommon but well-established complication of cranial irradiation is secondary neoplasm. This case presentation documents a radiation-induced malignant glioma 55 years after being diagnosed with “cerebral sarcoma,” now defined as atypical meningioma. This not only represents the longest reported latency period for a patient initially receiving over 30 Gy, but also provides a valuable historical perspective of neuro-oncology. Clinical Presentation: A 58-year-old female presenting with progressive left-sided upper and lower extremity weakness with a past medical history significant for “cerebral sarcoma” was diagnosed with glioblastoma multiforme. This patient had previously been treated with resection and adjuvant radiation therapy via a 280-kVP orthovoltage machine and received 3,390 rad to the posterior three-quarters of the skull for “cerebral sarcoma.” Conclusion: A comprehensive investigation of the past medical history helped uncover a mysterious pediatric diagnosis, helped drive the management 5 decades later, and serves as a reminder that seemingly safe interventions may still cause harm.