The special features of cardiovascular pathology diagnostics in patients with epilepsy

• Main Authors: Татьяна Анатольевна Литовченко, Валерия Николаевна Гримайло, Игорь Николаевич Пасюра, Анна Анатольевна Новикова
• Format: Article
• Language: English
• Published: PC Technology Center 2015-11-01
• Series: ScienceRise
• Subjects: epilepsy; cardiovascular pathology; myocardial work index; antiepileptic preparations; cardiovascular risk
• Online Access: http://journals.uran.ua/sciencerise/article/view/53995

<p><strong>Aim. </strong>The researchers noticed the changes of parameters of cardiovascular system functioning in patients with epilepsy during epileptic attacks and in interictal period. The aim of research was the study of informativity of the different methods of study of cardiovascular system functioning for detection and evaluation of risk of cardiac pathology development in patients with epilepsy.</p><p><strong>Materials and methods. </strong>We examined 50 patients with epilepsy and CVP and 50 patients with epilepsy without CVP. All patients underwent clinical and neurological examination, electrocardiography, echocardioscopy, examination of heart rhythm variability, dopplerography of carotid arteries, analysis of lipid blood spectrum, brain evaluation on indications on SCORE, МРТ.</p><p><strong>Results. </strong>There was revealed that the use of valproates and carbamazepine is associated with dyslipidemia development; valproates – with increase of intima-media complex thickness, cambamazepine – with increased risk of development of heart rhythm and conduction disorder; lamotrigine and levetiracetam – with increase of heart rate. The combined use of levetiracetam and carbamazepine is associated with extension of QT interval. The most significant increase of risk of CVP development during the next 10 years on SCORE was noticed in patients who take carbamazepine.</p><p><strong>Conclusions. </strong>The definition of intima-media complex thickness at dopplerography of carotid arteries, patients evaluation on SCORE, lipidograms, heart rhythm variability, definition of myocardial work index at echocardioscopy along with the standard ECG are effective for determination of risk factors and early detection of CVP in patients with epilepsy<em></em></p>