Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin

Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin

It is known that catechins interact with the tryptophan (Trp) residue at the drug-binding site of serum albumin. In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and human s...

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Bibliographic Details
Main Authors: Masaki Ikeda, Manabu Ueda-Wakagi, Kaori Hayashibara, Rei Kitano, Masaya Kawase, Kunihiro Kaihatsu, Nobuo Kato, Yoshitomo Suhara, Naomi Osakabe, Hitoshi Ashida
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
catechin
serum albumin
interaction
docking study
fluorescence analysis
Online Access:http://www.mdpi.com/1420-3049/22/2/314

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