Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies.
Rare variants of major effect play an important role in human complex diseases and can be discovered by sequencing-based genome-wide association studies. Here, we introduce an integrated approach that combines the rare variant association test with gene network and phenotype information to identify...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-12-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5760082?pdf=render |