Promising Noninvasive Cellular Phenotype in Prostate Cancer Cells Knockdown of Matrix Metalloproteinase 9

Promising Noninvasive Cellular Phenotype in Prostate Cancer Cells Knockdown of Matrix Metalloproteinase 9

Cell surface interaction of CD44 and MMP9 increases migration and invasion of PC3 cells. We show here that stable knockdown of MMP9 in PC3 cells switches CD44 isoform expression from CD44s to CD44v6 which is more glycosylated. These cells showed highly adhesive morphology with extensive cell spreadi...

Full description

Bibliographic Details
Main Authors:	Aditi Gupta, Wei Cao, Kavitha Sadashivaiah, Wantao Chen, Abraham Schneider, Meenakshi A. Chellaiah
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2013/493689

Similar Items

Membrane Localization of Membrane Type 1 Matrix Metalloproteinase by CD44 Regulates the Activation of Pro-Matrix Metalloproteinase 9 in Osteoclasts
by: Meenakshi A. Chellaiah, et al.
Published: (2013-01-01)

Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
by: Aditi Gupta, et al.
Published: (2013-05-01)

Cellular regulation of matrix metalloproteinase function
by: English, Jane Louise
Published: (2002)

The expression of matrix metalloproteinases in macrophage phenotypes
by: Huang, Wei-Chun
Published: (2011)

Integrin αvβ3 and CD44 pathways in metastatic prostate cancer cells support osteoclastogenesis via a Runx2/Smad 5/receptor activator of NF-κB ligand signaling axis
by: Gupta Aditi, et al.
Published: (2012-09-01)

EXPRESSION OF MATRIX METALLOPROTEINASE-9 IN ADENOCARCINOMA OF PROSTATE
by: M. I. Andruchin, et al.
Published: (2014-07-01)

EXPRESSION OF MATRIX METALLOPROTEINASE-9 IN ADENOCARCINOMA OF PROSTATE
by: M. I. Andruchin, et al.
Published: (2014-07-01)

Expression of matrix metalloproteinases and their inhibitors in prostate cancer
by: Still, Karen
Published: (1997)

Prediction of metastasis in oral squamous cell carcinoma through phenotypic evaluation and gene expression of E-cadherin, β-catenin, matrix metalloproteinase-2, and matrix metalloproteinase-9 biomarkers with clinical correlation
by: S V Sowmya, et al.
Published: (2020-01-01)

Versican in the wound healing matrix : cellular interactions and degradation by matrix metalloproteinases
by: Pourmalek, Saloumeh
Published: (2009)

Versican in the wound healing matrix : cellular interactions and degradation by matrix metalloproteinases
by: Pourmalek, Saloumeh
Published: (2009)

Versican in the wound healing matrix : cellular interactions and degradation by matrix metalloproteinases
by: Pourmalek, Saloumeh
Published: (2009)

Tissue Inhibitor of Matrix Metalloproteinases-1 Knockdown Suppresses the Proliferation of Human Adipose-Derived Stem Cells
by: Peihua Zhang, et al.
Published: (2016-01-01)

Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis
by: Jian-Da Ma, et al.
Published: (2014-01-01)

Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression
by: Yixuan Gong, et al.
Published: (2014-06-01)

Matrix metalloproteinases gene expression and their polymorphism in breast and prostate cancer
by: Schveigert, Diana
Published: (2014)

Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
by: Sroka, Isis Calsoyas
Published: (2007)

STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice.
by: Hai dong Li, et al.
Published: (2011-01-01)

Knockdown of N-Acetylglucosaminyltransferase-II Reduces Matrix Metalloproteinase 2 Activity and Suppresses Tumorigenicity in Neuroblastoma Cell Line
by: M. Kristen Hall, et al.
Published: (2020-04-01)

Biochemical and functional analysis of the mechanism for the cellular activation of matrix metalloproteinase 2
by: Atkinson, Susan Jane
Published: (2002)

Haemonchus contortus: siRNA mediated knockdown of matrix metalloproteinase 12A (MMP-12) results in reduction of infectivity
by: Muhammad Ali-ul-Husnain Naqvi, et al.
Published: (2020-03-01)

Matrix metalloproteinase 2 knockdown suppresses the proliferation of HepG2 and Huh7 cells and enhances the cisplatin effect
by: Liu Jiangwei, et al.
Published: (2019-05-01)

Diagnosis and Prognosis of Prostate Cancer from Circulating Matrix Metalloproteinases and Inhibitors
by: William Khalil El-Chaer, et al.
Published: (2018-01-01)

Expression of matrix metalloproteinase-9 and protein KI-67 at prostate tumors
by: M I Andrukhin, et al.
Published: (2014-12-01)

Matrix Metalloproteinases
by: S Sahitya, et al.
Published: (2010-01-01)

Matrix Metalloproteinase
Published: (2020)

Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in varicose veins
by: Florin Comsa, et al.
Published: (2010-06-01)

Serum Levels of Matrix Metalloproteinase-1 in Brazilian Patients with Benign Prostatic Hyperplasia or Prostate Cancer
by: William Khalil El-Chaer, et al.
Published: (2020-01-01)

MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF MATRIX METALLOPROTEINASES DURING PREGNANCY AND DELIVERY
by: Yu. V. Korenovsky, et al.
Published: (2012-09-01)

Expressions of matrix metalloproteinase-2 and extracellular matrix metalloproteinase inducer in retinoblastoma
by: Yu-Hong Cheng, et al.
Published: (2015-07-01)

The role of matrix metalloproteinases and vascular grouth facrors in differentional diagnostic of prostate’s diseases
by: V P Avdoshin, et al.
Published: (2014-12-01)

The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells.
by: Yong Jae Shin, et al.
Published: (2012-01-01)

Matrix metalloproteinases and atherosclerosis
by: Piotr Fic, et al.
Published: (2011-01-01)

Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients
by: Ivanišević Jasmina, et al.
Published: (2017-01-01)

Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells.
by: Hanan Aljohani, et al.
Published: (2019-01-01)

Cellular and Molecular Effects of High-Molecular-Weight Heparin on Matrix Metalloproteinase 9 Expression
by: René Huber, et al.
Published: (2019-03-01)

The phenotypic consequences of overexpression of matrix metalloproteinases and their inhibitors in a renal carcinoma cell line
by: Reid, Helen
Published: (2001)

Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells
by: Chellaiah Meenakshi A, et al.
Published: (2007-03-01)

Noninvasive Detection of Matrix Metalloproteinase Activity In Vivo using a Novel Magnetic Resonance Imaging Contrast Agent with a Solubility Switch
by: Martin Lepage, et al.
Published: (2007-11-01)

Matrix metalloproteinase-1 mediated extra-cellular matrix remodelling contributes to airway smooth muscle growth and asthma severity
by: Naveed, Shams-un-nisa
Published: (2018)