Vitamin D’s Effect on the Proliferation and Inflammation of Human Intervertebral Disc Cells in Relation to the Functional Vitamin D Receptor Gene FokI Polymorphism

Vitamin D’s Effect on the Proliferation and Inflammation of Human Intervertebral Disc Cells in Relation to the Functional Vitamin D Receptor Gene FokI Polymorphism

Vitamin D is known to have immunomodulatory effects, is involved in osteo-cartilaginous metabolism, and may have a role in human intervertebral disc pathophysiology. Although a link between vitamin D receptor (VDR) gene variants and disc degeneration-related pathologies has been observed, its functi...

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Bibliographic Details
Main Authors: Paola De Luca, Laura de Girolamo, Carlotta Perucca Orfei, Marco Viganò, Riccardo Cecchinato, Marco Brayda-Bruno, Alessandra Colombini
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
intervertebral disc
vitamin D
vitamin D receptor polymorphism
proliferation
inflammation
Online Access:http://www.mdpi.com/1422-0067/19/7/2002

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