Cell-Derived Microparticles in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis

• Main Authors: Sheyu Li, Jia Wei, Chenghui Zhang, Xiaodan Li, Wentong Meng, Xianming Mo, Qianying Zhang, Qilin Liu, Kaiyun Ren, Rong Du, Haoming Tian, Jianwei Li
• Format: Article
• Language: English
• Published: Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
• Series: Cellular Physiology and Biochemistry
• Subjects: Type 2 diabetes mellitus; Microparticles; Biomarker; Platelet-derived microparticle; Endothelium-derived microparticle
• Online Access: http://www.karger.com/Article/FullText/452512
• ISSN: 1015-8987; 1421-9778

Background/Aims: The aim of this study was to assess the association between circulating cell-derived microparticles (MPs) and type 2 diabetes mellitus (T2DM). Methods: A literature search was performed systematically in PubMed and Embase to identify available case-control or cross-sectional studies that compared different types of cell-derived MPs in patients with T2DM and non-diabetic controls. Pooled standardized mean differences (SMDs) of each MP type were pooled using meta-analysis. Results: Forty-eight studies involving 2,460 patients with T2DM and 1,880 non-diabetic controls were included for systematic review and 34 of which were included for quantitative study by meta-analysis. In the overall analysis, the levels of circulating total MPs (TMPs), platelet-derived MPs (PMPs), monocyte-derived MPs (MMPs) and endothelium-derived MPs (EMPs) were significantly higher in T2DM patients than those in controls (TMPs: SMD, 0.64; 95%CI, 0.12∼1.15; P=0.02; PMPs: SMD, 1.19; 95%CI, 0.88∼1.50; P Conclusions: The counts of TMPs, PMPs, MMPs and EMPs elevated in patients with T2DM. And cell-derived MPs may play a role in the pathogenesis of T2DM.