Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.

BACKGROUND: In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that knockout mice for Eps8, a regulator of actin...

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Bibliographic Details
Main Authors: Arianna Tocchetti, Charlotte Blanche Ekalle Soppo, Fabio Zani, Fabrizio Bianchi, Maria Cristina Gagliani, Benedetta Pozzi, Jan Rozman, Ralf Elvert, Nicole Ehrhardt, Birgit Rathkolb, Corinna Moerth, Marion Horsch, Helmut Fuchs, Valérie Gailus-Durner, Johannes Beckers, Martin Klingenspor, Eckhard Wolf, Martin Hrabé de Angelis, Eugenio Scanziani, Carlo Tacchetti, Giorgio Scita, Pier Paolo Di Fiore, Nina Offenhäuser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2830459?pdf=render

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