Bridging Synaptic and Epigenetic Maintenance Mechanisms of the Engram

How memories are maintained, and how memories are lost during aging or disease, are intensely investigated issues. Arguably, the reigning theory is that synaptic modifications allow for the formation of engrams during learning, and sustaining engrams sustains memory. Activity-regulated gene expressi...

Full description

Bibliographic Details
Main Authors: Madeleine Kyrke-Smith, Joanna M. Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
LTP
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00369/full