Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance

Hepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribu...

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Main Authors:	Zhongliang Shen, Huijuan Yang, Sisi Yang, Wei Wang, Xiaoxian Cui, Xian Zhou, Wei Liu, Shaokun Pan, Yanfeng Liu, Junqi Zhang, Jiming Zhang, Youhua Xie, Jing Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02304-7

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spelling	doaj-2a6ebc55834f4e11b5c6b0b8ed9ae5112021-05-11T07:04:03ZengNature Publishing GroupNature Communications2041-17232017-12-018111110.1038/s41467-017-02304-7Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearanceZhongliang Shen0Huijuan Yang1Sisi Yang2Wei Wang3Xiaoxian Cui4Xian Zhou5Wei Liu6Shaokun Pan7Yanfeng Liu8Junqi Zhang9Jiming Zhang10Youhua Xie11Jing Liu12Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityDepartment of Infectious Diseases, Huashan Hospital, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan UniversityHepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribute to clearance.https://doi.org/10.1038/s41467-017-02304-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhongliang Shen Huijuan Yang Sisi Yang Wei Wang Xiaoxian Cui Xian Zhou Wei Liu Shaokun Pan Yanfeng Liu Junqi Zhang Jiming Zhang Youhua Xie Jing Liu
spellingShingle	Zhongliang Shen Huijuan Yang Sisi Yang Wei Wang Xiaoxian Cui Xian Zhou Wei Liu Shaokun Pan Yanfeng Liu Junqi Zhang Jiming Zhang Youhua Xie Jing Liu Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance Nature Communications
author_facet	Zhongliang Shen Huijuan Yang Sisi Yang Wei Wang Xiaoxian Cui Xian Zhou Wei Liu Shaokun Pan Yanfeng Liu Junqi Zhang Jiming Zhang Youhua Xie Jing Liu
author_sort	Zhongliang Shen
title	Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_short	Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_full	Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_fullStr	Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_full_unstemmed	Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
title_sort	hepatitis b virus persistence in mice reveals il-21 and il-33 as regulators of viral clearance
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Hepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribute to clearance.
url	https://doi.org/10.1038/s41467-017-02304-7
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Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance

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