Regulation of CaV1.2 Current: Interaction With Intracellular Molecules

Regulation of CaV1.2 Current: Interaction With Intracellular Molecules

CaV1.2 (α1c) is a pore-forming subunit of the voltage-dependent L-type calcium channel and is expressed in many tissues. The β and α2/δ subunits are auxiliary subunits that affect the kinetics and the expression of CaV1.2. In addition to the β and α2/δ subunits, several molecules have been reported...

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Bibliographic Details
Main Authors: Takeshi Kobayashi, Yoichi Yamada, Mitsuhiro Fukao, Masaaki Tsutsuura, Noritsugu Tohse
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319342884
Description
Summary:CaV1.2 (α1c) is a pore-forming subunit of the voltage-dependent L-type calcium channel and is expressed in many tissues. The β and α2/δ subunits are auxiliary subunits that affect the kinetics and the expression of CaV1.2. In addition to the β and α2/δ subunits, several molecules have been reported to be involved in the regulation of CaV1.2 current. Calmodulin, CaBP1 (calcium-binding protein-1), CaMKII (calcium/calmodulin-dependent protein kinase II), AKAPs (A-kinase anchoring proteins), phosphatases, Caveolin-3, β2-adrenergic receptor, PDZ domain proteins, sorcin, SNARE proteins, synaptotagmin, CSN5, RGK family, and AHNAK1 have all been reported to interact with CaV1.2 and the β subunit. This review focuses on the effect of these molecules on CaV1.2 current. Keywords:: CaV1.2, calcium, channel, current
ISSN:1347-8613

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