PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling

PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling

Abstract Objectives A role for the type II arginine methyltransferase PRMT5 in various human diseases has been identified. In this study, the potential mechanism underlying the involvement of PRMT5 in the pathological process leading to osteoarthritis (OA) was investigated. Methods PRMT5 expression...

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Bibliographic Details
Main Authors: Yonghui Dong, Ping Wang, Yongguang Yang, Jincheng Huang, Zhipeng Dai, Wendi Zheng, Zhen Li, Zheng Yao, Hongjun Zhang, Jia Zheng
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
PRMT5
Chondrocytes
Kinases
DMM model
Online Access:http://link.springer.com/article/10.1186/s13075-020-02304-x

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