Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

An increasing number of amyloid structures are determined. Here, the authors present the structure-based amyloid core sequence prediction method Cordax that is based on machine learning and allows the detection of aggregation-prone regions with higher solubility, disorder and surface exposure, and f...

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Main Authors: Nikolaos Louros, Gabriele Orlando, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17207-3
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spelling doaj-2a64a32adfa14ef9a2a2d237d6f0b10b2021-07-04T11:47:16ZengNature Publishing GroupNature Communications2041-17232020-07-0111111310.1038/s41467-020-17207-3Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilitiesNikolaos Louros0Gabriele Orlando1Matthias De Vleeschouwer2Frederic Rousseau3Joost Schymkowitz4Switch Laboratory, VIB Center for Brain and Disease ResearchSwitch Laboratory, VIB Center for Brain and Disease ResearchSwitch Laboratory, VIB Center for Brain and Disease ResearchSwitch Laboratory, VIB Center for Brain and Disease ResearchSwitch Laboratory, VIB Center for Brain and Disease ResearchAn increasing number of amyloid structures are determined. Here, the authors present the structure-based amyloid core sequence prediction method Cordax that is based on machine learning and allows the detection of aggregation-prone regions with higher solubility, disorder and surface exposure, and furthermore predicts the structural topology, orientation and overall architecture of the resulting putative fibril core.https://doi.org/10.1038/s41467-020-17207-3
collection DOAJ
language English
format Article
sources DOAJ
author Nikolaos Louros
Gabriele Orlando
Matthias De Vleeschouwer
Frederic Rousseau
Joost Schymkowitz
spellingShingle Nikolaos Louros
Gabriele Orlando
Matthias De Vleeschouwer
Frederic Rousseau
Joost Schymkowitz
Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
Nature Communications
author_facet Nikolaos Louros
Gabriele Orlando
Matthias De Vleeschouwer
Frederic Rousseau
Joost Schymkowitz
author_sort Nikolaos Louros
title Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_short Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_full Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_fullStr Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_full_unstemmed Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
title_sort structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description An increasing number of amyloid structures are determined. Here, the authors present the structure-based amyloid core sequence prediction method Cordax that is based on machine learning and allows the detection of aggregation-prone regions with higher solubility, disorder and surface exposure, and furthermore predicts the structural topology, orientation and overall architecture of the resulting putative fibril core.
url https://doi.org/10.1038/s41467-020-17207-3
work_keys_str_mv AT nikolaoslouros structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities
AT gabrieleorlando structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities
AT matthiasdevleeschouwer structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities
AT fredericrousseau structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities
AT joostschymkowitz structurebasedmachineguidedmappingofamyloidsequencespacerevealsunchartedsequenceclusterswithhighersolubilities
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