Prospective Evaluation of Local Sustained Release of Celecoxib in Dogs with Low Back Pain

Prospective Evaluation of Local Sustained Release of Celecoxib in Dogs with Low Back Pain

Back pain affects millions globally and in 40% of the cases is attributed to intervertebral disc degeneration. Oral analgesics are associated with adverse systemic side-effects and insufficient pain relief. Local drug delivery mitigates systemic effects and accomplishes higher local dosing. Clinical...

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Bibliographic Details
Main Authors: Tijn Wiersema, Anna R. Tellegen, Martijn Beukers, Marijn van Stralen, Erik Wouters, Mandy van de Vooren, Nina Woike, George Mihov, Jens C. Thies, Laura B. Creemers, Marianna A. Tryfonidou, Björn P. Meij
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
non-steroidal anti-inflammatory drugs
biomaterials
controlled release
intervertebral disc degeneration
microspheres
degenerative lumbosacral stenosis
Online Access:https://www.mdpi.com/1999-4923/13/8/1178

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