Myocardial Hypertrophy and Fibrosis Are Associated with Cardiomyocyte Beta-Catenin and TRPC6/Calcineurin/NFAT Signaling in Spontaneously Hypertensive Rats with 5/6 Nephrectomy

Myocardial Hypertrophy and Fibrosis Are Associated with Cardiomyocyte Beta-Catenin and TRPC6/Calcineurin/NFAT Signaling in Spontaneously Hypertensive Rats with 5/6 Nephrectomy

Background: Arterial hypertension (AH) is associated with heart and chronic kidney disease (CKD). However, the precise mechanisms of myocardial remodeling (MR) in the settings of CKD remain elusive. We hypothesized that TRPC6, calcineurin/NFAT, and Wnt/β-catenin signaling pathways are involved in th...

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Bibliographic Details
Main Authors: Evdokia Bogdanova, Olga Beresneva, Olga Galkina, Irina Zubina, Galina Ivanova, Marina Parastaeva, Natalia Semenova, Vladimir Dobronravov
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
arterial hypertension
cardiac remodeling
chronic kidney disease
calcineurin A
calcineurin B
NFAT
Online Access:https://www.mdpi.com/1422-0067/22/9/4645

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