Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy

Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy

Oxaliplatin (L-OHP) is widely prescribed for treating gastroenterological cancer. L-OHP-induced peripheral neuropathy is a critical toxic effect that limits the dosage of L-OHP. An ideal chemotherapeutic strategy that does not result in severe peripheral neuropathy but confers high anticancer effica...

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Bibliographic Details
Main Authors:	Shinji Kobuchi, Risa Shimizu, Yukako Ito
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Pharmaceutics
Subjects:	pharmacokinetic-toxicodynamic modeling peripheral neuropathy cancer chemotherapy platinum compound personalized therapy toxicology
Online Access:	https://www.mdpi.com/1999-4923/12/2/125

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