Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults

Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults

Lactobacillus johnsonii N6.2 mitigates the onset of type 1 diabetes (T1D) in biobreeding diabetes-prone rats, in part, through changes in kynurenine:tryptophan (K:T) ratios. The goal of this pilot study was to determine the safety, tolerance, and general immunological response of L. johnsonii N6.2 i...

Full description

Bibliographic Details
Main Authors:	Guillermo E. Marcial, Amanda L. Ford, Michael J. Haller, Salvador A. Gezan, Natalie A. Harrison, Dan Cai, Julie L. Meyer, Daniel J. Perry, Mark A. Atkinson, Clive H. Wasserfall, Timothy Garrett, Claudio F. Gonzalez, Todd M. Brusko, Wendy J. Dahl, Graciela L. Lorca
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-06-01
Series:	Frontiers in Immunology
Subjects:	Lactobacillus johnsonii diabetes type I probiotic indoleamine-2,3-dioxygenase microbiome gastrointestinal symptom
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00655/full

Similar Items

Identification of Biomarkers for Systemic Distribution of Nanovesicles From Lactobacillus johnsonii N6.2
by: Natalie A. Harrison, et al.
Published: (2021-08-01)

Sex Modulates Lactobacillus johnsonii N6.2 and Phytophenol Effectiveness in Reducing High Fat Diet Induced mTOR Activation in Sprague-Dawley Rats
by: Danielle N. Kling, et al.
Published: (2018-11-01)

H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein.
by: Ricardo B Valladares, et al.
Published: (2015-07-01)

Exoproteome Perspective on the Bile Stress Response of <i>Lactobacillus johnsonii</i>
by: Bernadette B. Bagon, et al.
Published: (2021-02-01)

Probiotic Lactobacillus johnsonii BS15 Improves Blood Parameters Related to Immunity in Broilers Experimentally Infected with Subclinical Necrotic Enteritis
by: Hesong Wang, et al.
Published: (2018-01-01)

Heat-Killed Lactobacillus salivarius and Lactobacillus johnsonii Reduce Liver Injury Induced by Alcohol In Vitro and In Vivo
by: Cheng-Hung Chuang, et al.
Published: (2016-10-01)

Antimicrobial Resistance of <i>Lactobacillus johnsonii</i> and <i>Lactobacillus zeae</i> in Raw Milk
by: Jana Výrostková, et al.
Published: (2020-12-01)

Effects of Lactobacillus Johnsonii AJ5 Metabolites on Nutrition, Nosema Ceranae Development and Performance of Apis Mellifera L.
by: Piano Fiorella G. De, et al.
Published: (2017-06-01)

Whole-Genome Analysis of Two Copies of blaNDM-1 Gene Carrying Acinetobacter johnsonii Strain Acsw19 Isolated from Sichuan, China
by: Tang L, et al.
Published: (2020-03-01)

Analysis of hepatic transcriptome demonstrates altered lipid metabolism following Lactobacillus johnsonii BS15 prevention in chickens with subclinical necrotic enteritis
by: Xiaodan Qing, et al.
Published: (2018-04-01)

Complete Genome Sequencing and Comparative Genome Characterization of Lactobacillus johnsonii ZLJ010, a Potential Probiotic With Health-Promoting Properties
by: Wei Zhang, et al.
Published: (2019-09-01)

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens
by: Xiaodan Qing, et al.
Published: (2017-06-01)

Bile-Salt-Hydrolases from the Probiotic Strain Lactobacillus johnsonii La1 Mediate Anti-giardial Activity in Vitro and in Vivo
by: Thibault Allain, et al.
Published: (2018-01-01)

Tryptophan-degrading enzymes in tumoral immune resistance
by: Nicolas van Baren, et al.
Published: (2016-11-01)

What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past
by: Yu Yao, et al.
Published: (2021-02-01)

Lactobacillus johnsonii CJLJ103 attenuates colitis and memory impairment in mice by inhibiting gut microbiota lipopolysaccharide production and NF-κB activation
by: Su-Min Lim, et al.
Published: (2017-07-01)

Lactobacillus johnsonii BS15 improves intestinal environment against fluoride-induced memory impairment in mice—a study based on the gut–brain axis hypothesis
by: Jinge Xin, et al.
Published: (2020-10-01)

Psychoactive Effects of Lactobacillus johnsonii Against Restraint Stress-Induced Memory Dysfunction in Mice Through Modulating Intestinal Inflammation and permeability—a Study Based on the Gut–Brain Axis Hypothesis
by: Hesong Wang, et al.
Published: (2021-05-01)

A Novel Low-Temperature Alkaline Lipase from Acinetobacter johnsonii LP28 Suitable for Detergent Formulation
by: Hai Kuan Wang, et al.
Published: (2011-01-01)

Isolation and Genomic Characterization of an Acinetobacter johnsonii Bacteriophage AJO2 From Bulking Activated Sludge
by: Niansi Fan, et al.
Published: (2019-02-01)

Effect of a lotion containing the heat-treated probiotic strain Lactobacillus johnsonii NCC 533 on Staphylococcus aureus colonization in atopic dermatitis
by: Blanchet-Réthoré S, et al.
Published: (2017-07-01)

The 14kDa Protein Molecule Isolated from Garlic Suppresses Indoleamine 2, 3-Dioxygenase Metabolites in Mononuclear Cells In vitro
by: Nikoo Shohreh, et al.
Published: (2008-12-01)

The Immunoregulatory Function of Indoleamine 2, 3 Dioxygenase and Its Application in Allotransplantation
by: Reza B. Jalili, et al.
Published: (2007-12-01)

Indoleamine 2,3-dioxygenase (IDO): Only an enzyme or a checkpoint controller?
by: Cemil Bilir, M.D., et al.
Published: (2017-07-01)

Antiviral activity of interferon-γ involved in impaired immune function in infectious diseases
by: Sucher Robert, et al.
Published: (2013-12-01)

Non-Viable <i>Lactobacillus johnsonii</i> JNU3402 Protects against Diet-Induced Obesity
by: Garam Yang, et al.
Published: (2020-10-01)

TRYPTOPHAN AND INDOLEAMINE-2,3-DIOXYGENASE (IDO) IN PATHOGENESIS OF IMMUNOSUPPRESSIVE CLINICAL CONDITIONS
by: V. A. Kozlov, et al.
Published: (2017-07-01)

The Kynurenine Pathway As a Novel Link between Allergy and the Gut Microbiome
by: Aaron P. Van der Leek, et al.
Published: (2017-11-01)

Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.
by: Ricardo Valladares, et al.
Published: (2010-01-01)

Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma’s Anti-BKPyV Activity in Renal Cells
by: Tony Fiore, et al.
Published: (2020-08-01)

Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study
by: Mengyan Wang, et al.
Published: (2019-03-01)

Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy
by: Soranobu Ninomiya, et al.
Published: (2020-04-01)

Kynurenines and Multiple Sclerosis: The Dialogue between the Immune System and the Central Nervous System
by: Cecilia Rajda, et al.
Published: (2015-08-01)

Effect of Indoleamine 2,3 Dioxygenase Inhibitor on the Cytotoxic Activity of Tumour-infiltrating Lymphocytes
by: Sarah Le Naour, et al.
Published: (2019-08-01)

Expression and Prognostic Value of Indoleamine 2,3-dioxygenase in Pancreatic Cancer
by: Tao Zhang, et al.
Published: (2017-01-01)

Wine and Grape Juice Modulate Interferon-y-induced Neopterin Production and Tryptophan Degradation in Human PBMC
by: Neurauter Gabriele, et al.
Published: (2004-02-01)

Serum neopterin concentrations and tryptophan degradation pattern in patients with late stage larynx carcinoma
by: Engin Ayse Basak, et al.
Published: (2017-08-01)

Neopterin suppresses the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase in human peripheral blood mononuclear cells
by: Schroecksnadel Sebastian, et al.
Published: (2013-12-01)

Phylogeographical Analyses and Antibiotic Resistance Genes of Acinetobacter johnsonii Highlight Its Clinical Relevance
by: Santiago Castillo-Ramírez, et al.
Published: (2020-07-01)

The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
by: Knut A. Hestad, et al.
Published: (2017-10-01)

Cannot write session to /tmp/vufind_sessions/sess_incepmjc62f7lmkslokijagrsb