Entering an era of dynamic structural biology…
Abstract A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and...
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2018-05-01
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| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-018-0533-4 |
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doaj-2a2746f46c2d4e5ab59636928ff38c682020-11-24T22:06:51ZengBMCBMC Biology1741-70072018-05-011611410.1186/s12915-018-0533-4Entering an era of dynamic structural biology…Allen M. Orville0Diamond Light Source, Research Complex at Harwell, and University of OxfordAbstract A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and inactivation of the antibiotic ceftriaxone by a β-lactamase enzyme from Mycobacterium tuberculosis. Their work demonstrates the general applicability of time-resolved crystallography, from which dynamic structures, at atomic resolution, can be obtained. See research article: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0524-5.http://link.springer.com/article/10.1186/s12915-018-0533-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Allen M. Orville |
| spellingShingle |
Allen M. Orville Entering an era of dynamic structural biology… BMC Biology |
| author_facet |
Allen M. Orville |
| author_sort |
Allen M. Orville |
| title |
Entering an era of dynamic structural biology… |
| title_short |
Entering an era of dynamic structural biology… |
| title_full |
Entering an era of dynamic structural biology… |
| title_fullStr |
Entering an era of dynamic structural biology… |
| title_full_unstemmed |
Entering an era of dynamic structural biology… |
| title_sort |
entering an era of dynamic structural biology… |
| publisher |
BMC |
| series |
BMC Biology |
| issn |
1741-7007 |
| publishDate |
2018-05-01 |
| description |
Abstract A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and inactivation of the antibiotic ceftriaxone by a β-lactamase enzyme from Mycobacterium tuberculosis. Their work demonstrates the general applicability of time-resolved crystallography, from which dynamic structures, at atomic resolution, can be obtained. See research article: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0524-5. |
| url |
http://link.springer.com/article/10.1186/s12915-018-0533-4 |
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