Investigating the Role of Methylation in Silencing of <i>VDR</i> Gene Expression in Normal Cells during Hematopoiesis and in Their Leukemic Counterparts

Investigating the Role of Methylation in Silencing of <i>VDR</i> Gene Expression in Normal Cells during Hematopoiesis and in Their Leukemic Counterparts

(1) <i>Background</i>: Vitamin D receptor (VDR) is present in multiple types of blood cells, and its ligand, 1,25-dihydroxyvitamin D (1,25D), is important for the proper functioning of the immune system. Activity of VDR is higher in hematopoietic stem and progenitor cells than in fully d...

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Bibliographic Details
Main Authors: Urszula Nowak, Sylwia Janik, Aleksandra Marchwicka, Agnieszka Łaszkiewicz, Agnieszka Jakuszak, Małgorzata Cebrat, Ewa Marcinkowska
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
blood cells
vitamin D receptor
gene expression
hematopoietic stem cells
hematopoietic progenitor cells
differentiation
Online Access:https://www.mdpi.com/2073-4409/9/9/1991

Internet

https://www.mdpi.com/2073-4409/9/9/1991

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