T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

Crucial roles for T-box3 in development are evident by severe limb malformations and other birth defects caused by T-box3 mutations in humans. Mechanisms whereby T-box3 regulates limb development are poorly understood. We discovered requirements for T-box at multiple stages of mouse limb development...

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Bibliographic Details
Main Authors: Uchenna Emechebe, Pavan Kumar P, Julian M Rozenberg, Bryn Moore, Ashley Firment, Tooraj Mirshahi, Anne M Moon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
cilia
limb development
hedgehog
gli3
kif7
tbx3
Online Access:https://elifesciences.org/articles/07897

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