Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Abstract Multiple Sclerosis (MS) is the most common cause of acquired neurological disability in young adults, pathologically characterized by leukocyte infiltration of the central nervous system, demyelination of the white and grey matter, and subsequent axonal loss. Microglia are proposed to play...

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Bibliographic Details
Main Authors: Thecla A. van Wageningen, Eva Vlaar, Gijs Kooij, Cornelis A. M. Jongenelen, Jeroen J. G. Geurts, Anne-Marie van Dam
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis
Homeostatic microglia
Cortical lesions
Demyelination
Subpial lesions
Online Access:https://doi.org/10.1186/s40478-019-0850-z

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