| Summary: | Abstract
There are limited studies reporting on the health related quality of life (HRQL) of patients with end stage renal disease living in non-industrialized countries. This study describes the underlying relationships among determinants of HRQL in patients under renal replacement treatment. A cross-sectional design was used with a sample of 243 patients attending five hemodialysis and peritoneal dialysis centers of Montevideo (mean age 56.6 years, SD 16.2; 58% males). A univariate linear regression analysis was performed for each independent variable. A total of 61 independent variables were included: biological/clinical, sociodemographic, and psychosocial. HRQL outcomes were evaluated using the SF-36 Health Survey eight subscales, Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Variables shown to have significant association in the univariate analysis (p<0.10) were included in a multivariate regression analysis. Ten regression models were studied, for the 8 SF-36 subscales, PCS and MCS scores. Fifteen variables were significant in the multivariable models; time in renal replacement treatment, urea, creatinine, haemoglobin, iron, hospitalizations, acute illness, blindness, age, gender, living with someone, working status, administration of antidepressants or antipsychotic medications, and maintenance of sex life, explaining 43% of the variance of PCS and 35% of MCS. The type and relevance of the explanatory variables differed along the various dimensions of HRQL. As a conclusion we underline the entwining of biological, sociodemographic and psychosocial factors as determinants of health related quality of life patients with end stage renal disease, thus supporting the multidimensional definition and modelling of the construct.
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