Lewy body dementia: Ursodeoxycholic acid as a putative treatment for gastrointestinal dysfunction

• Main Author: Mohsen Khosravi
• Format: Article
• Language: English
• Published: PAGEPress Publications 2021-06-01
• Series: European Journal of Translational Myology
• Subjects: Gastrointestinal dysfunction; Lewy body dementia; ursodeoxycholic acid
• Online Access: https://www.pagepressjournals.org/index.php/bam/article/view/9876

The autonomic nervous system (ANS) is a part of the peripheral nervous system that regulates internal organs function at an involuntary unconscious level. Recent evidence has shown that autonomic dysfunction is a common feature of Lewy body dementia (LBD). A wide range of autonomic symptoms may occur in LBD, which are correlated with poor prognosis. However, there is still no evidence-based approach to developing the best therapeutic strategy for autonomic dysfunction (particularly gastrointestinal symptoms) among LBD patients. This paper was intended to present a new perspective on ursodeoxycholic acid and its potential effects for treating gastrointestinal dysfunction in LBD patients.