A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.

A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.

Yeast cells can be killed upon expression of pro-apoptotic mammalian proteins. We have established a functional yeast survival screen that was used to isolate novel human anti-apoptotic genes overexpressed in treatment-resistant tumors. The screening of three different cDNA libraries prepared from m...

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Bibliographic Details
Main Authors: Moritz Eißmann, Bettina Schwamb, Inga Maria Melzer, Julia Moser, Dagmar Siele, Ulrike Köhl, Ralf Joachim Rieker, David Lukas Wachter, Abbas Agaimy, Esther Herpel, Peter Baumgarten, Michel Mittelbronn, Stefanie Rakel, Donat Kögel, Stefanie Böhm, Tony Gutschner, Sven Diederichs, Martin Zörnig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3661464?pdf=render

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