Mesenchymal stem cells derived from iPSCs expressing interleukin-24 inhibit the growth of melanoma in the tumor-bearing mouse model

Mesenchymal stem cells derived from iPSCs expressing interleukin-24 inhibit the growth of melanoma in the tumor-bearing mouse model

Abstract Background Interleukin-24 (IL-24) is a therapeutic gene for melanoma, which can induce melanoma cell apoptosis. Mesenchymal stem cells (MSCs) show promise as a carrier to delivery anti-cancer factors to tumor tissues. Induced pluripotent stem cells (iPSCs) are an alternative source of mesen...

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Bibliographic Details
Main Authors: Zheng Wu, Wei Liu, Zujia Wang, Baitao Zeng, Guangnan Peng, Hongyan Niu, Linlin Chen, Cong Liu, Qian Hu, Yuxuan Zhang, Mengmeng Pan, Lingqian Wu, Mujun Liu, Xionghao Liu, Desheng Liang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cancer Cell International
Subjects:
iPSCs-derived MSCs
Human rDNA locus
Site-specific Integration
Interleukin-24
Melanoma
Online Access:https://doi.org/10.1186/s12935-020-1112-7

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