Study on establishment of esophageal carcinoma animal models

• Main Authors: ZHAO Qiang, WEN Danyi, SUN Jianhe
• Format: Article
• Language: English
• Published: Academic Journals Center of Shanghai Normal University 2013-08-01
• Series: Journal of Shanghai Normal University (Natural Sciences)
• Subjects: esophageal carcinoma animal models; induced models; transplantation models; magnetic resonance imaging; in vivo imaging
• Online Access: http://qktg.shnu.edu.cn/zrb/shsfqkszrb/ch/reader/create_pdf.aspx?file_no=201304012&year_id=2013&quarter_id=4&falg=1

Esophageal cancer is one of the common human gastrointestinal malignancies.In recent years,the global incidence of esophageal cancer and its mortality rise.China is the high incidence area of esophageal cancer with the highest morbidity and mortality in the world.However,the exact pathogeny of esophageal cancer has not been fully clarified yet.Thus,it is of significant importance to establish ideal and stable esophageal carcinoma animal models with similar biological characteristics to clinical tumors,which will provide a reliable research basis for the occurrence,development,metastasis and drug responses of esophageal carcinoma,and is also helpful for anti-esophageal cancer drug screening and the development of rational dinical therapeutic treatment.This article provides an overview of the development of esophageal carcinoma animal models in recent years,the classification of esophageal carcinoma animal models,modeling methods and the progress of model evaluation.