Whole Blood Transcriptome Profiling Identifies DNA Replication and Cell Cycle Regulation as Early Marker of Response to Anti-PD-1 in Patients with Urothelial Cancer

Whole Blood Transcriptome Profiling Identifies DNA Replication and Cell Cycle Regulation as Early Marker of Response to Anti-PD-1 in Patients with Urothelial Cancer

Although immune checkpoint inhibitors improve median overall survival in patients with metastatic urothelial cancer (mUC), only a minority of patients benefit from it. Early blood-based response biomarkers may provide a reliable way to assess response weeks before imaging is available, enabling an e...

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Bibliographic Details
Main Authors: Sandra van Wilpe, Victoria Wosika, Laura Ciarloni, Sahar Hosseinian Ehrensberger, Rachel Jeitziner, Paolo Angelino, Tjitske Duiveman-de Boer, Rutger H. T. Koornstra, I. Jolanda M. de Vries, Winald R. Gerritsen, Jack Schalken, Niven Mehra
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
urothelial cancer
anti-PD-1
biomarkers
proliferation
transcriptome
Online Access:https://www.mdpi.com/2072-6694/13/18/4660

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