Running Exercise Alleviates Pain and Promotes Cell Proliferation in a Rat Model of Intervertebral Disc Degeneration

Running Exercise Alleviates Pain and Promotes Cell Proliferation in a Rat Model of Intervertebral Disc Degeneration

Chronic low back pain accompanied by intervertebral disk degeneration is a common musculoskeletal disorder. Physical exercise, which is clinically recommended by international guidelines, has proven to be effective for degenerative disc disease (DDD) patients. However, the mechanism underlying the a...

Full description

Bibliographic Details
Main Authors:	Shuo Luan, Qing Wan, Haijie Luo, Xiao Li, Songjian Ke, Caina Lin, Yuanyuan Wu, Shaoling Wu, Chao Ma
Format:	Article
Language:	English
Published:	MDPI AG 2015-01-01
Series:	International Journal of Molecular Sciences
Subjects:	degenerative disc disease (DDD) running exercise cell proliferation disc regeneration
Online Access:	http://www.mdpi.com/1422-0067/16/1/2130

Similar Items

Hypo-Osmotic Loading Induces Expression of IL-6 in Nucleus Pulposus Cells of the Intervertebral Disc Independent of TRPV4 and TRPM7
by: Aleksandra Sadowska, et al.
Published: (2020-07-01)

The role of infection and inflammation in intervertebral disc degeneration
by: Oksana G. Prudnikova, et al.
Published: (2018-03-01)

Tissue Engineering Strategies for Intervertebral Disc Treatment Using Functional Polymers
by: Youngjoo Choi, et al.
Published: (2019-05-01)

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration—Correlation with histological grading in a rabbit disc degeneration model
by: Kyle Sheldrick, et al.
Published: (2019-09-01)

MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology
by: Petra Cazzanelli, et al.
Published: (2020-05-01)

Lumbar Herniated Degenerated Disc: Simple Discectomy or Fusion?
by: Alaa Abou-Shousha
Published: (2013-01-01)

The role of infectious pathogens in etiopathogenesis of degenerative intervertebral disc diseases
by: Mark M. Alexanyan, et al.
Published: (2020-06-01)

Impact of pulse sequence, analysis method, and signal to noise ratio on the accuracy of intervertebral disc T2 measurement
by: Kyle D. Meadows, et al.
Published: (2020-09-01)

Cervical degenerative disc disease: epidemiology, natural history, clinical presentation.
by: L. Kollintzas
Published: (2017-03-01)

Effect of Pb exposure on the cells and matrix of the intervertebral disc of rats
by: V. Maltseva
Published: (2017-04-01)

Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration
by: Zoe Krut, et al.
Published: (2021-08-01)

MRI Evaluation of Lumbar Disc Degenerative Disease
by: Pokhraj Suthar, et al.
Published: (2015-04-01)

Medium-term outcomes of artificial disc replacement for severe cervical disc narrowing
by: Chao-Hung Yeh, et al.
Published: (2014-01-01)

Reliable Magnetic Resonance Imaging Based Grading System for Cervical Intervertebral Disc Degeneration
by: Lloydine J. Jacobs, et al.
Published: (2016-02-01)

Notochord Cells in Intervertebral Disc Development and Degeneration
by: Matthew R. McCann, et al.
Published: (2016-01-01)

Prognostic factors in the progression of intervertebral disc degeneration: Which patient should be targeted with regenerative therapies?
by: Christine M. E. Rustenburg, et al.
Published: (2019-09-01)

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy
by: Christopher Centeno, et al.
Published: (2017-09-01)

Finite element study of a lumbar intervertebral disc nucleus replacement device
by: Jessica S Coogan, et al.
Published: (2016-12-01)

Do the disc degeneration and osteophyte contribute to the curve rigidity of degenerative scoliosis?
by: Feng Zhu, et al.
Published: (2017-03-01)

The potential of CRISPR/Cas9 genome editing for the study and treatment of intervertebral disc pathologies
by: Olga Krupkova, et al.
Published: (2018-03-01)

BACK PAIN ASSOCIATED WITH INTERVERTEBRAL DISK DEGENERATION: MORPHOLOGICAL, GENETIC AND CLINICO-INSTRUMENTAL ASPECTS
by: N. A. Shostak, et al.
Published: (2014-07-01)

BACK PAIN ASSOCIATED WITH INTERVERTEBRAL DISK DEGENERATION: MORPHOLOGICAL, GENETIC AND CLINICO-INSTRUMENTAL ASPECTS
by: N. A. Shostak, et al.
Published: (2014-07-01)

Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma
by: Shanmuganathan Rajasekaran, et al.
Published: (2020-06-01)

Analysis of crucial molecules involved in herniated discs and degenerative disc disease
by: Zhigang Qu, et al.
Published: (2013-01-01)

The Impact of Smoking on Radiological Outcomes in Patients After Total Arthroplasty of the Cervical Intervertebral Discs
by: I. A. Stepanov, et al.
Published: (2020-11-01)

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage
by: P Roughley, et al.
Published: (2006-01-01)

Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration
by: Kennon Justin C., et al.
Published: (2018-05-01)

Morphological and radiographic parameters of facet joints and their dependence on the grade of intervertebral disc degeneration
by: Artem E. Krivoshein, et al.
Published: (2020-12-01)

Relationships Between Disc Degeneration and Autophagy Expression in Human Nucleus Pulposus
by: Meiling Quan, et al.
Published: (2020-02-01)

Pathomechanism of intervertebral disc degeneration
by: Takeshi Oichi, et al.
Published: (2020-03-01)

Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease
by: Pang Hung Wu, et al.
Published: (2020-03-01)

Results of transforaminal endoscopic discectomy for lumbosacral disc herniation added by nucleoplasty
by: Medetbek D. Abakirov, et al.
Published: (2021-04-01)

Autophagy and mTOR signaling during intervertebral disc aging and degeneration
by: Takashi Yurube, et al.
Published: (2020-03-01)

Lumbar Disc Herniations in Children. A Five-Year Single Center Experience
by: Horatiu Alexandru MOISA, et al.
Published: (2021-06-01)

Relation between grades of intervertebral disc degeneration and occupational activities of patients with lumbar disc herniation
by: Papić Monika, et al.
Published: (2017-01-01)

Clinical and radiographic outcomes of cervical disc arthroplasty with Prestige-LP Disc: a minimum 6-year follow-up study
by: Junfeng Zeng, et al.
Published: (2018-08-01)

Genetic Markers of a Predisposition to Lumbar Disc Degeneration in Young Adults
Published: (2016)

The Mechanisms and Functions of GDF‐5 in Intervertebral Disc Degeneration
by: Sheng Guo, et al.
Published: (2021-05-01)

Development of a Unique Mouse Intervertebral Disc Degeneration Model Using a Simple Novel Tool
by: Manish Baldia, et al.
Published: (2021-08-01)

HISTOLOGICAL MARKERS OF DEGENERATION AND REGENERATION OF THE HUMAN INTERVERTEBRAL DISK
by: MANUELA PELETTI-FIGUEIRÓ, et al.

Cannot write session to /tmp/vufind_sessions/sess_frpi3m20c2qjl5l1tjkthstm3t