Vitamin E-modulated gene expression associated with ROS generation

Although the beneficial effects of vitamin E on reactive oxygen species (ROS)-related diseases, such as cardiovascular disease (CVD), have been suggested by epidemiological and animal studies, clinical trials have failed to confirm the efficacy of vitamin E. Vitamin E has a defined role as an antiox...

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Main Authors: Yukiko K. Nakamura, Stanley T. Omaye
Format: Article
Language:English
Published: Elsevier 2009-07-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464609000164
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spelling doaj-29b7b0e2841648c1b435cbc8a3a200cc2021-04-29T04:39:38ZengElsevierJournal of Functional Foods1756-46462009-07-0113241252Vitamin E-modulated gene expression associated with ROS generationYukiko K. Nakamura0Stanley T. Omaye1Department of Nutrition, Environmental Sciences Graduate Program, Mail Stop 142, University of Nevada, Reno, NV 89557, United StatesCorresponding author.; Department of Nutrition, Environmental Sciences Graduate Program, Mail Stop 142, University of Nevada, Reno, NV 89557, United StatesAlthough the beneficial effects of vitamin E on reactive oxygen species (ROS)-related diseases, such as cardiovascular disease (CVD), have been suggested by epidemiological and animal studies, clinical trials have failed to confirm the efficacy of vitamin E. Vitamin E has a defined role as an antioxidant. Recent studies indicate non-antioxidant roles of vitamin E serving as a regulator of gene/protein expression and enzyme inhibitor. Vitamin E may control ROS generation possibly in both antioxidant-dependent and independent manners, since vitamin E has shown inhibitory effects on activities and expression of ROS generating enzymes. However, the effects of vitamin E appear to depend on microenvironment, such as its concentration and the presence of oxidants/antioxidants. The objective of this article is to review the roles of vitamin E, in particular vitamin E-modulated gene expression, for better understanding the molecular mechanisms of vitamin E and for preventive and therapeutic strategies of ROS-related diseases.http://www.sciencedirect.com/science/article/pii/S1756464609000164Vitamin ETocopherolAntioxidantsReactive oxygen species
collection DOAJ
language English
format Article
sources DOAJ
author Yukiko K. Nakamura
Stanley T. Omaye
spellingShingle Yukiko K. Nakamura
Stanley T. Omaye
Vitamin E-modulated gene expression associated with ROS generation
Journal of Functional Foods
Vitamin E
Tocopherol
Antioxidants
Reactive oxygen species
author_facet Yukiko K. Nakamura
Stanley T. Omaye
author_sort Yukiko K. Nakamura
title Vitamin E-modulated gene expression associated with ROS generation
title_short Vitamin E-modulated gene expression associated with ROS generation
title_full Vitamin E-modulated gene expression associated with ROS generation
title_fullStr Vitamin E-modulated gene expression associated with ROS generation
title_full_unstemmed Vitamin E-modulated gene expression associated with ROS generation
title_sort vitamin e-modulated gene expression associated with ros generation
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2009-07-01
description Although the beneficial effects of vitamin E on reactive oxygen species (ROS)-related diseases, such as cardiovascular disease (CVD), have been suggested by epidemiological and animal studies, clinical trials have failed to confirm the efficacy of vitamin E. Vitamin E has a defined role as an antioxidant. Recent studies indicate non-antioxidant roles of vitamin E serving as a regulator of gene/protein expression and enzyme inhibitor. Vitamin E may control ROS generation possibly in both antioxidant-dependent and independent manners, since vitamin E has shown inhibitory effects on activities and expression of ROS generating enzymes. However, the effects of vitamin E appear to depend on microenvironment, such as its concentration and the presence of oxidants/antioxidants. The objective of this article is to review the roles of vitamin E, in particular vitamin E-modulated gene expression, for better understanding the molecular mechanisms of vitamin E and for preventive and therapeutic strategies of ROS-related diseases.
topic Vitamin E
Tocopherol
Antioxidants
Reactive oxygen species
url http://www.sciencedirect.com/science/article/pii/S1756464609000164
work_keys_str_mv AT yukikoknakamura vitaminemodulatedgeneexpressionassociatedwithrosgeneration
AT stanleytomaye vitaminemodulatedgeneexpressionassociatedwithrosgeneration
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