Vitamin E-modulated gene expression associated with ROS generation
Although the beneficial effects of vitamin E on reactive oxygen species (ROS)-related diseases, such as cardiovascular disease (CVD), have been suggested by epidemiological and animal studies, clinical trials have failed to confirm the efficacy of vitamin E. Vitamin E has a defined role as an antiox...
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doaj-29b7b0e2841648c1b435cbc8a3a200cc2021-04-29T04:39:38ZengElsevierJournal of Functional Foods1756-46462009-07-0113241252Vitamin E-modulated gene expression associated with ROS generationYukiko K. Nakamura0Stanley T. Omaye1Department of Nutrition, Environmental Sciences Graduate Program, Mail Stop 142, University of Nevada, Reno, NV 89557, United StatesCorresponding author.; Department of Nutrition, Environmental Sciences Graduate Program, Mail Stop 142, University of Nevada, Reno, NV 89557, United StatesAlthough the beneficial effects of vitamin E on reactive oxygen species (ROS)-related diseases, such as cardiovascular disease (CVD), have been suggested by epidemiological and animal studies, clinical trials have failed to confirm the efficacy of vitamin E. Vitamin E has a defined role as an antioxidant. Recent studies indicate non-antioxidant roles of vitamin E serving as a regulator of gene/protein expression and enzyme inhibitor. Vitamin E may control ROS generation possibly in both antioxidant-dependent and independent manners, since vitamin E has shown inhibitory effects on activities and expression of ROS generating enzymes. However, the effects of vitamin E appear to depend on microenvironment, such as its concentration and the presence of oxidants/antioxidants. The objective of this article is to review the roles of vitamin E, in particular vitamin E-modulated gene expression, for better understanding the molecular mechanisms of vitamin E and for preventive and therapeutic strategies of ROS-related diseases.http://www.sciencedirect.com/science/article/pii/S1756464609000164Vitamin ETocopherolAntioxidantsReactive oxygen species |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yukiko K. Nakamura Stanley T. Omaye |
spellingShingle |
Yukiko K. Nakamura Stanley T. Omaye Vitamin E-modulated gene expression associated with ROS generation Journal of Functional Foods Vitamin E Tocopherol Antioxidants Reactive oxygen species |
author_facet |
Yukiko K. Nakamura Stanley T. Omaye |
author_sort |
Yukiko K. Nakamura |
title |
Vitamin E-modulated gene expression associated with ROS generation |
title_short |
Vitamin E-modulated gene expression associated with ROS generation |
title_full |
Vitamin E-modulated gene expression associated with ROS generation |
title_fullStr |
Vitamin E-modulated gene expression associated with ROS generation |
title_full_unstemmed |
Vitamin E-modulated gene expression associated with ROS generation |
title_sort |
vitamin e-modulated gene expression associated with ros generation |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2009-07-01 |
description |
Although the beneficial effects of vitamin E on reactive oxygen species (ROS)-related diseases, such as cardiovascular disease (CVD), have been suggested by epidemiological and animal studies, clinical trials have failed to confirm the efficacy of vitamin E. Vitamin E has a defined role as an antioxidant. Recent studies indicate non-antioxidant roles of vitamin E serving as a regulator of gene/protein expression and enzyme inhibitor. Vitamin E may control ROS generation possibly in both antioxidant-dependent and independent manners, since vitamin E has shown inhibitory effects on activities and expression of ROS generating enzymes. However, the effects of vitamin E appear to depend on microenvironment, such as its concentration and the presence of oxidants/antioxidants. The objective of this article is to review the roles of vitamin E, in particular vitamin E-modulated gene expression, for better understanding the molecular mechanisms of vitamin E and for preventive and therapeutic strategies of ROS-related diseases. |
topic |
Vitamin E Tocopherol Antioxidants Reactive oxygen species |
url |
http://www.sciencedirect.com/science/article/pii/S1756464609000164 |
work_keys_str_mv |
AT yukikoknakamura vitaminemodulatedgeneexpressionassociatedwithrosgeneration AT stanleytomaye vitaminemodulatedgeneexpressionassociatedwithrosgeneration |
_version_ |
1721502136589615104 |