diffBUM-HMM: a robust statistical modeling approach for detecting RNA flexibility changes in high-throughput structure probing data

diffBUM-HMM: a robust statistical modeling approach for detecting RNA flexibility changes in high-throughput structure probing data

Abstract Advancing RNA structural probing techniques with next-generation sequencing has generated demands for complementary computational tools to robustly extract RNA structural information amidst sampling noise and variability. We present diffBUM-HMM, a noise-aware model that enables accurate det...

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Bibliographic Details
Main Authors: Paolo Marangio, Ka Ying Toby Law, Guido Sanguinetti, Sander Granneman
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Biology
Subjects:
Hidden Markov model
High-throughput RNA structure probing
RNA structural changes
Online Access:https://doi.org/10.1186/s13059-021-02379-y

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