A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine
Abstract Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes. We report a case of a 56-year-old man with CBM, identified as Fonsecaea pedrosoi infection by fungal c...
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Adis, Springer Healthcare
2020-02-01
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| Series: | Dermatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s13555-020-00358-y |
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doaj-29b520c1486f4ffeaa0c42f92e5e5a382021-02-21T12:15:40ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722020-02-0110232132710.1007/s13555-020-00358-yA Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with TerbinafineXu-Cheng Shen0Xiang-Nong Dai1Zhi-Min Xie2Ping Li3Sha Lu4Jia-Hao Li5Yi Zhang6Xing-Dong Ye7Department of Dermatology, Dermatology Institute of Guangzhou Medical University, Guangzhou Medical UniversityDepartment of Dermatology, Dermatology Institute of Guangzhou Medical University, Guangzhou Medical UniversityDepartment of Dermatology, Dermatology Institute of Guangzhou Medical University, Guangzhou Medical UniversityDepartment of Dermatology, Dermatology Institute of Guangzhou Medical University, Guangzhou Medical UniversityDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Dermatology, Guangzhou Institute of DermatologyDepartment of Dermatology, Dermatology Institute of Guangzhou Medical University, Guangzhou Medical UniversityAbstract Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes. We report a case of a 56-year-old man with CBM, identified as Fonsecaea pedrosoi infection by fungal culture and gene sequencing. This patient was successfully treated with a regimen of oral itraconazole (ITZ) and terbinafine lasting 7 months. Through in vitro drug sensitivity tests, minimum inhibitory concentrations of amphotericin, ITZ, and terbinafine were 1 μg/ml, 0.25 μg/ml, and 1 μg/ml, respectively. In this case, terbinafine was found to be more effective than ITZ.https://doi.org/10.1007/s13555-020-00358-yChromoblastomycosisFonsecaea pedrosoiFungal gene sequencingIn vitro antifungal susceptibilityTerbinafine |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xu-Cheng Shen Xiang-Nong Dai Zhi-Min Xie Ping Li Sha Lu Jia-Hao Li Yi Zhang Xing-Dong Ye |
| spellingShingle |
Xu-Cheng Shen Xiang-Nong Dai Zhi-Min Xie Ping Li Sha Lu Jia-Hao Li Yi Zhang Xing-Dong Ye A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine Dermatology and Therapy Chromoblastomycosis Fonsecaea pedrosoi Fungal gene sequencing In vitro antifungal susceptibility Terbinafine |
| author_facet |
Xu-Cheng Shen Xiang-Nong Dai Zhi-Min Xie Ping Li Sha Lu Jia-Hao Li Yi Zhang Xing-Dong Ye |
| author_sort |
Xu-Cheng Shen |
| title |
A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine |
| title_short |
A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine |
| title_full |
A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine |
| title_fullStr |
A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine |
| title_full_unstemmed |
A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine |
| title_sort |
case of chromoblastomycosis caused by fonsecaea pedrosoi successfully treated by oral itraconazole together with terbinafine |
| publisher |
Adis, Springer Healthcare |
| series |
Dermatology and Therapy |
| issn |
2193-8210 2190-9172 |
| publishDate |
2020-02-01 |
| description |
Abstract Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes. We report a case of a 56-year-old man with CBM, identified as Fonsecaea pedrosoi infection by fungal culture and gene sequencing. This patient was successfully treated with a regimen of oral itraconazole (ITZ) and terbinafine lasting 7 months. Through in vitro drug sensitivity tests, minimum inhibitory concentrations of amphotericin, ITZ, and terbinafine were 1 μg/ml, 0.25 μg/ml, and 1 μg/ml, respectively. In this case, terbinafine was found to be more effective than ITZ. |
| topic |
Chromoblastomycosis Fonsecaea pedrosoi Fungal gene sequencing In vitro antifungal susceptibility Terbinafine |
| url |
https://doi.org/10.1007/s13555-020-00358-y |
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