Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.

A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which com...

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Main Authors: Meng Wu, Ziwen Wang, Chuisong Meng, Kailiang Wang, Yanna Hu, Lizhong Wang, Qingmin Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3572066?pdf=render
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spelling doaj-29b318e3d8b7418da01aee05cdfd58ae2020-11-25T02:15:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5647510.1371/journal.pone.0056475Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.Meng WuZiwen WangChuisong MengKailiang WangYanna HuLizhong WangQingmin WangA series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.http://europepmc.org/articles/PMC3572066?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Meng Wu
Ziwen Wang
Chuisong Meng
Kailiang Wang
Yanna Hu
Lizhong Wang
Qingmin Wang
spellingShingle Meng Wu
Ziwen Wang
Chuisong Meng
Kailiang Wang
Yanna Hu
Lizhong Wang
Qingmin Wang
Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
PLoS ONE
author_facet Meng Wu
Ziwen Wang
Chuisong Meng
Kailiang Wang
Yanna Hu
Lizhong Wang
Qingmin Wang
author_sort Meng Wu
title Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
title_short Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
title_full Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
title_fullStr Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
title_full_unstemmed Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
title_sort discovery and sars of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (tmv) agents.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.
url http://europepmc.org/articles/PMC3572066?pdf=render
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