Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which com...
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doaj-29b318e3d8b7418da01aee05cdfd58ae2020-11-25T02:15:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5647510.1371/journal.pone.0056475Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.Meng WuZiwen WangChuisong MengKailiang WangYanna HuLizhong WangQingmin WangA series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.http://europepmc.org/articles/PMC3572066?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meng Wu Ziwen Wang Chuisong Meng Kailiang Wang Yanna Hu Lizhong Wang Qingmin Wang |
spellingShingle |
Meng Wu Ziwen Wang Chuisong Meng Kailiang Wang Yanna Hu Lizhong Wang Qingmin Wang Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. PLoS ONE |
author_facet |
Meng Wu Ziwen Wang Chuisong Meng Kailiang Wang Yanna Hu Lizhong Wang Qingmin Wang |
author_sort |
Meng Wu |
title |
Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. |
title_short |
Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. |
title_full |
Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. |
title_fullStr |
Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. |
title_full_unstemmed |
Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents. |
title_sort |
discovery and sars of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (tmv) agents. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection. |
url |
http://europepmc.org/articles/PMC3572066?pdf=render |
work_keys_str_mv |
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