Presynaptic Calcium Channel Open Probability and Changes in Calcium Influx Throughout the Action Potential Determined Using AP-Waveforms

Presynaptic Calcium Channel Open Probability and Changes in Calcium Influx Throughout the Action Potential Determined Using AP-Waveforms

Action potentials arriving at a nerve terminal activate voltage-gated calcium channels and set the electrical driving force for calcium entry which affects the amount and duration of neurotransmitter release. During propagation, the duration, amplitude, and shape of action potentials often changes....

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Bibliographic Details
Main Authors: Matthew S. Scarnati, Stephen G. Clarke, Zhiping P. Pang, Kenneth G. Paradiso
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
action potential
calcium channels
local calcium concentration
nanodomains
microdomains
open probability
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2020.00017/full

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https://www.frontiersin.org/article/10.3389/fnsyn.2020.00017/full

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