Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

Abstract S. cerevisiae Hal3 (ScHal3) is a moonlighting protein that, is in its monomeric state, regulates the Ser/Thr protein phosphatase Ppz1, but also joins ScCab3 (and in some instances the Hal3 paralog Vhs3) to form an unusual heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzy...

Full description

Bibliographic Details
Main Authors: Carlos Santolaria, Diego Velázquez, Erick Strauss, Joaquín Ariño
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Schally
Phosphopantothenoylcysteine Decarboxylase
Plasmid pWS12
Native AtHal3
Hall Variety
Online Access:https://doi.org/10.1038/s41598-018-32979-x

Internet

https://doi.org/10.1038/s41598-018-32979-x

Similar Items