Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant...

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Main Authors:	Kenichi Yoshida, Tetsuya Shimizugawa, Mitsuru Ono, Hidehiko Furukawa
Format:	Article
Language:	English
Published:	Elsevier 2002-11-01
Series:	Journal of Lipid Research
Subjects:	KK/San intravenous injection plasma triglyceride
Online Access:	http://www.sciencedirect.com/science/article/pii/S002222752032753X

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spelling	doaj-299dfd8456164b91b1a21c6cf1b7c5ca2021-04-27T04:42:55ZengElsevierJournal of Lipid Research0022-22752002-11-01431117701772Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipaseKenichi Yoshida0Tetsuya Shimizugawa1Mitsuru Ono2Hidehiko Furukawa3Biomedical Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan; Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JapanBiomedical Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan; Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JapanBiomedical Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan; Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JapanBiomedical Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan; Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JapanStudies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein.Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro.http://www.sciencedirect.com/science/article/pii/S002222752032753XKK/Sanintravenous injectionplasma triglyceride
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kenichi Yoshida Tetsuya Shimizugawa Mitsuru Ono Hidehiko Furukawa
spellingShingle	Kenichi Yoshida Tetsuya Shimizugawa Mitsuru Ono Hidehiko Furukawa Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase Journal of Lipid Research KK/San intravenous injection plasma triglyceride
author_facet	Kenichi Yoshida Tetsuya Shimizugawa Mitsuru Ono Hidehiko Furukawa
author_sort	Kenichi Yoshida
title	Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
title_short	Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
title_full	Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
title_fullStr	Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
title_full_unstemmed	Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
title_sort	angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
publisher	Elsevier
series	Journal of Lipid Research
issn	0022-2275
publishDate	2002-11-01
description	Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein.Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro.
topic	KK/San intravenous injection plasma triglyceride
url	http://www.sciencedirect.com/science/article/pii/S002222752032753X
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Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

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