Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders

Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders

AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to...

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Bibliographic Details
Main Authors: Helen Wong, Josien Levenga, Lauren LaPlante, Bailey Keller, Andrew Cooper-Sansone, Curtis Borski, Ryan Milstead, Marissa Ehringer, Charles Hoeffer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
extinction
hippocampus
prefrontal cortex
isoform
associative memory
spatial learning
Online Access:https://elifesciences.org/articles/56630

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