Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging

• Main Authors: Yan Gao, Jian Kang, Zhen Lei, Yankun Li, Xifan Mei, Guannan Wang
• Format: Article
• Language: English
• Published: SpringerOpen 2020-03-01
• Series: Nanoscale Research Letters
• Subjects: Biocompatibility; AuNC@PEGs; Contrast agent; In vivo CT imaging
• Online Access: http://link.springer.com/article/10.1186/s11671-020-3286-2
• ISSN: 1931-7573; 1556-276X

Abstract In recent years, contrast agents have been widely used in imaging technology to improve quality. Nanoparticles have better in vivo detection capability than conventional molecular scale contrast agents. In this study, a new type of Au nanocages@PEG nanoparticles (AuNC@PEGs) with a strong X-ray absorption coefficient was synthesized as a contrast agent for computed tomography (CT) scan imaging. Results showed that AuNC@PEGs had good aqueous dispensation, low cytotoxicity, and strong X-ray absorption ability. Furthermore, in vivo studies have shown that the synthesized AuNC@PEGs have an evident contrast enhancement, long circulation time in the blood, and negligible toxicity in vivo. Therefore, the synthesized functionalized AuNC@PEGs in this study have great potential for clinical application in CT scan imaging.