A semantics-oriented computational approach to investigate microRNA regulation on glucocorticoid resistance in pediatric acute lymphoblastic leukemia

A semantics-oriented computational approach to investigate microRNA regulation on glucocorticoid resistance in pediatric acute lymphoblastic leukemia

Abstract Background Acute lymphoblastic leukemia is the most prevalent neoplasia among children. Despite the tremendous achievements of state-of-the-art treatment strategies, drug resistance is still a major cause of chemotherapy failure leading to relapse in pediatric acute lymphoblastic leukemia....

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Bibliographic Details
Main Authors: Huiqin Chen, Dihua Zhang, Guoping Zhang, Xiaofeng Li, Ying Liang, Mohan Vamsi Kasukurthi, Shengyu Li, Glen M. Borchert, Jingshan Huang
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Medical Informatics and Decision Making
Subjects:
Acute lymphoblastic leukemia (ALL)
Drug resistance
microRNA (miRNA or miR)
Glucocorticoids (GC)
miRNA target
Biomedical and biological ontology (bio-ontology)
Online Access:http://link.springer.com/article/10.1186/s12911-018-0637-3

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http://link.springer.com/article/10.1186/s12911-018-0637-3

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