Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factori...

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Bibliographic Details
Main Authors: Makarand Suresh Gambhire, Mangesh Ramesh Bhalekar, Vaishali Makarand Gambhire
Format: Article
Language:English
Published: Universidade de São Paulo 2011-09-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Nanopartículas lipídicas sólidas
Homogeneização
Ultrasonicação
Planejamento fatorial
Ditranol
Solid lipid nanoparticles
Homogenization
Ultrasonication
3² factorial design
Dithranol
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300008

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