Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein

Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein

Oligomerization, conformational changes, and the consequent neurodegeneration of Alzheimer's β-amyloid protein (AβP) play crucial roles in the pathogenesis of Alzheimer's disease (AD). Mounting evidence suggests that oligomeric AβPs cause the disruption of calcium homeostasis, eventually l...

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Bibliographic Details
Main Authors:	Masahiro Kawahara, Isao Ohtsuka, Shoko Yokoyama, Midori Kato-Negishi, Yutaka Sadakane
Format:	Article
Language:	English
Published:	Hindawi Limited 2011-01-01
Series:	International Journal of Alzheimer's Disease
Online Access:	http://dx.doi.org/10.4061/2011/304583

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