Emergence of cytotoxic resistance in cancer cell populations*

Emergence of cytotoxic resistance in cancer cell populations*

We formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system....

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Main Authors: Lorenzi Tommaso, Chisholm Rebecca H., Lorz Alexander, Larsen Annette K., de Almeida Luís Neves, Escargueil Alexandre, Clairambault Jean
Format: Article
Language:English
Published: EDP Sciences 2015-01-01
Series:ITM Web of Conferences
Online Access:http://dx.doi.org/10.1051/itmconf/20150500009
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spelling doaj-296830d10d4548808e95b75dd9ecca262021-02-02T04:08:17ZengEDP SciencesITM Web of Conferences2271-20972015-01-0150000910.1051/itmconf/20150500009itmconf_mod2015_00009Emergence of cytotoxic resistance in cancer cell populations*Lorenzi Tommaso0Chisholm Rebecca H.1Lorz Alexander2Larsen Annette K.3de Almeida Luís Neves4Escargueil Alexandre5Clairambault Jean6Centre de Mathématiques et de Leurs Applications, ENS Cachan, CNRS, CachanSchool of Biotechnology and Biomolecular Sciences, University of New South WalesSorbonne Universités, UPMC Univ Paris 06, CNRS, INRIA, UMR 7598, Laboratoire Jacques-Louis Lions, Équipe MAMBASorbonne Universités, UPMC Univ Paris 06Sorbonne Universités, UPMC Univ Paris 06, CNRS, INRIA, UMR 7598, Laboratoire Jacques-Louis Lions, Équipe MAMBASorbonne Universités, UPMC Univ Paris 06Sorbonne Universités, UPMC Univ Paris 06, CNRS, INRIA, UMR 7598, Laboratoire Jacques-Louis Lions, Équipe MAMBAWe formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.http://dx.doi.org/10.1051/itmconf/20150500009
collection DOAJ
language English
format Article
sources DOAJ
author Lorenzi Tommaso
Chisholm Rebecca H.
Lorz Alexander
Larsen Annette K.
de Almeida Luís Neves
Escargueil Alexandre
Clairambault Jean
spellingShingle Lorenzi Tommaso
Chisholm Rebecca H.
Lorz Alexander
Larsen Annette K.
de Almeida Luís Neves
Escargueil Alexandre
Clairambault Jean
Emergence of cytotoxic resistance in cancer cell populations*
ITM Web of Conferences
author_facet Lorenzi Tommaso
Chisholm Rebecca H.
Lorz Alexander
Larsen Annette K.
de Almeida Luís Neves
Escargueil Alexandre
Clairambault Jean
author_sort Lorenzi Tommaso
title Emergence of cytotoxic resistance in cancer cell populations*
title_short Emergence of cytotoxic resistance in cancer cell populations*
title_full Emergence of cytotoxic resistance in cancer cell populations*
title_fullStr Emergence of cytotoxic resistance in cancer cell populations*
title_full_unstemmed Emergence of cytotoxic resistance in cancer cell populations*
title_sort emergence of cytotoxic resistance in cancer cell populations*
publisher EDP Sciences
series ITM Web of Conferences
issn 2271-2097
publishDate 2015-01-01
description We formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.
url http://dx.doi.org/10.1051/itmconf/20150500009
work_keys_str_mv AT lorenzitommaso emergenceofcytotoxicresistanceincancercellpopulations
AT chisholmrebeccah emergenceofcytotoxicresistanceincancercellpopulations
AT lorzalexander emergenceofcytotoxicresistanceincancercellpopulations
AT larsenannettek emergenceofcytotoxicresistanceincancercellpopulations
AT dealmeidaluisneves emergenceofcytotoxicresistanceincancercellpopulations
AT escargueilalexandre emergenceofcytotoxicresistanceincancercellpopulations
AT clairambaultjean emergenceofcytotoxicresistanceincancercellpopulations
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