Novel Methods of Incorporating Time in Longitudinal Multivariate Analysis Reveals Hidden Associations With Disease Activity in Systemic Lupus Erythematosus

Novel Methods of Incorporating Time in Longitudinal Multivariate Analysis Reveals Hidden Associations With Disease Activity in Systemic Lupus Erythematosus

Objective: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. SLE is characterized by high inter-patient variability, including fluctuations over time, a factor which most biomarker studies omit from consideration. We investigated relationships between disease activity and bioma...

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Bibliographic Details
Main Authors: Hieu T. Nim, Kathryn Connelly, Fabien B. Vincent, François Petitjean, Alberta Hoi, Rachel Koelmeyer, Sarah E. Boyd, Eric F. Morand
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
biomarkers
clustering
longitudinal analysis
regression models
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01649/full

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