Intermittent Hypobaric Hypoxic Preconditioning Provides Neuroprotection by Increasing Antioxidant Activity, Erythropoietin Expression and Preventing Apoptosis and Astrogliosis in the Brain of Adult Rats Exposed to Acute Severe Hypoxia

Intermittent Hypobaric Hypoxic Preconditioning Provides Neuroprotection by Increasing Antioxidant Activity, Erythropoietin Expression and Preventing Apoptosis and Astrogliosis in the Brain of Adult Rats Exposed to Acute Severe Hypoxia

Background: Exposure to intermittent hypoxia has been demonstrated to be an efficient tool for hypoxic preconditioning, preventing damage to cells and demonstrating therapeutic benefits. We aimed to evaluate the effects of respiratory intermittent hypobaric hypoxia (IHH) to avoid brain injury caused...

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Bibliographic Details
Main Authors: Débora Coimbra-Costa, Fernando Garzón, Norma Alva, Tiago C. C. Pinto, Fernando Aguado, Joan Ramon Torrella, Teresa Carbonell, Ramón Rama
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis-inducing factor
erythropoietin
glial fibrillary acidic protein
glutathione
HIF
NF-κB
Online Access:https://www.mdpi.com/1422-0067/22/10/5272

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