Abnormal Crosstalk between Endothelial Cells and Podocytes Mediates Tyrosine Kinase Inhibitor (TKI)-Induced Nephrotoxicity

Abnormal Crosstalk between Endothelial Cells and Podocytes Mediates Tyrosine Kinase Inhibitor (TKI)-Induced Nephrotoxicity

Vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2 are the main targets of antiangiogenic therapies, and proteinuria is one of the common adverse events associated with the inhibition of the VEGFA/VEGFR2 pathway. The proteinuric kidney damage induced by VEGFR2 tyrosine kinase inhib...

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Bibliographic Details
Main Authors: Xiaoying Gu, Su Zhang, Ti Zhang
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
angiogenesis
tyrosine kinase inhibitors
nephrotoxicity
endothelial cells
podocytes
crosstalk
Online Access:https://www.mdpi.com/2073-4409/10/4/869

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