Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design

Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design

The chemical elements of proteins are similar to that of DNA (e.g., C, H, O, and N), and DNA shows different knotted architectures. So we imagine that proteins may show a wealth of highly complex structures, especially when proteins interact with each other. The imagination was proved by synthesizin...

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Main Authors: Yumin Leng, Chunhua Ma, Wentai Zhang, Kecheng Liu, Zhiwen Lu
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2018/8540172
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spelling doaj-29167ce0d0734b649131350cfc4ea3a42020-11-24T22:56:51ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292018-01-01201810.1155/2018/85401728540172Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array DesignYumin Leng0Chunhua Ma1Wentai Zhang2Kecheng Liu3Zhiwen Lu4College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061, ChinaCollege of Mechanical and Electronic Engineering, Nanyang Normal University, Nanyang 473061, ChinaCollege of Mechanical and Electronic Engineering, Nanyang Normal University, Nanyang 473061, ChinaCollege of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, ChinaCollege of Physics and Electronic Engineering, Nanyang Normal University, Nanyang 473061, ChinaThe chemical elements of proteins are similar to that of DNA (e.g., C, H, O, and N), and DNA shows different knotted architectures. So we imagine that proteins may show a wealth of highly complex structures, especially when proteins interact with each other. The imagination was proved by synthesizing gold nanoparticles (GNPs) to capture the lifelike protein structures. The optical responses (i.e., color) of as-prepared GNPs are found to be characteristic to a given protein (or heavy metal ion). Based on the “three colors” principle of Thomas Young, we extracted the red, green, and blue (RGB) alterations of as-synthesized GNPs to fabricate multichannel sensor arrays for proteins (or heavy metal ions) discrimination. The designed multichannel sensor arrays demonstrate possibilities in semiquantitative analysis of multiple analytes (e.g., proteins and heavy metal ions). This work is believed to open new opportunities for GNPs-based label-free sensing.http://dx.doi.org/10.1155/2018/8540172
collection DOAJ
language English
format Article
sources DOAJ
author Yumin Leng
Chunhua Ma
Wentai Zhang
Kecheng Liu
Zhiwen Lu
spellingShingle Yumin Leng
Chunhua Ma
Wentai Zhang
Kecheng Liu
Zhiwen Lu
Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design
Journal of Nanomaterials
author_facet Yumin Leng
Chunhua Ma
Wentai Zhang
Kecheng Liu
Zhiwen Lu
author_sort Yumin Leng
title Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design
title_short Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design
title_full Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design
title_fullStr Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design
title_full_unstemmed Synthesis of Gold Nanoparticles to Capture Lifelike Proteins: Application on the Multichannel Sensor Array Design
title_sort synthesis of gold nanoparticles to capture lifelike proteins: application on the multichannel sensor array design
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2018-01-01
description The chemical elements of proteins are similar to that of DNA (e.g., C, H, O, and N), and DNA shows different knotted architectures. So we imagine that proteins may show a wealth of highly complex structures, especially when proteins interact with each other. The imagination was proved by synthesizing gold nanoparticles (GNPs) to capture the lifelike protein structures. The optical responses (i.e., color) of as-prepared GNPs are found to be characteristic to a given protein (or heavy metal ion). Based on the “three colors” principle of Thomas Young, we extracted the red, green, and blue (RGB) alterations of as-synthesized GNPs to fabricate multichannel sensor arrays for proteins (or heavy metal ions) discrimination. The designed multichannel sensor arrays demonstrate possibilities in semiquantitative analysis of multiple analytes (e.g., proteins and heavy metal ions). This work is believed to open new opportunities for GNPs-based label-free sensing.
url http://dx.doi.org/10.1155/2018/8540172
work_keys_str_mv AT yuminleng synthesisofgoldnanoparticlestocapturelifelikeproteinsapplicationonthemultichannelsensorarraydesign
AT chunhuama synthesisofgoldnanoparticlestocapturelifelikeproteinsapplicationonthemultichannelsensorarraydesign
AT wentaizhang synthesisofgoldnanoparticlestocapturelifelikeproteinsapplicationonthemultichannelsensorarraydesign
AT kechengliu synthesisofgoldnanoparticlestocapturelifelikeproteinsapplicationonthemultichannelsensorarraydesign
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