Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

Abstract Background The NLRP3-mediated pyroptosis, which could be regulated by miRNA-27a, is a key player in the development of depression. Isoliquiritin is a phenolic flavonoid compound that has been demonstrated to suppress NLRP3-mediated pyroptosis. However, it is still unknown whether isoliquiri...

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Bibliographic Details
Main Authors: Yuanjie Li, Wen Song, Yue Tong, Xia Zhang, Jianjun Zhao, Xiaojuan Gao, Jingjiao Yong, Hanqing Wang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Depression
miRNA-27a
NLRP3
Pyroptosis
Isoliquiritin
Online Access:https://doi.org/10.1186/s12974-020-02040-8

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